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Issue 0, 1972
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Microbiological hydroxylation of steroids. Part V. The pattern of hydroxylation of dioxygenated 5α-androstanes with cultures of the fungus Calonectria decora

Abstract

Dioxygenated 5α-androstanes are more readily hydroxylated with Calonectria decora than the mono-oxygenated substrates studied previously. Oxygen functions in rings A and D act as primary directing groups and, when a blocking effect by middle ring substituents is allowed for, the pattern of hydroxylation is predictable in most cases.

1β-Hydroxy-compounds are obtained in moderate yields from the readily accessible 5α-androstane-6,17- and 7,17-diones.

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Article type: Paper
DOI: 10.1039/P19720002759
J. Chem. Soc., Perkin Trans. 1, 1972, 2759-2765

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    Microbiological hydroxylation of steroids. Part V. The pattern of hydroxylation of dioxygenated 5α-androstanes with cultures of the fungus Calonectria decora

    A. M. Bell, W. A. Denny, E. R. H. Jones, G. D. Meakins and W. E. Müller, J. Chem. Soc., Perkin Trans. 1, 1972, 2759
    DOI: 10.1039/P19720002759

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