Flavofungin: a mixture of 13,15,17,19,21,23,25,27-octahydroxy-31-isopropyl-14-methyl- and 13,15,17,19,21,23,25,27-octahydroxy-14-methyl-31-s-butyl-hentriaconta-2,4,6,8,10,28-hexaen-31-olide

Abstract

Flavofungin, the antifungal antibiotic from Streptomyces flavofungini, has been shown to be a mixture (ca. 10:1) of 13,15,17,19,21,23,25,27-octahydroxy-31-isopropyl-14-methyl-(1a) and 13,15,17,19,21,23,25,27-octahydroxy-14-methyl-31-s-butyl-(1b) hentriaconta-2,4,6,8,10,23-hexaen-31-olide. Its relationship to mycoticin is discussed.