Polypeptides. Part XIII. Peptides related to the C-terminal tetrapeptide sequence of the gastrins by complementary reading of the genetic message

Abstract

Messenger RNA sequences which will code for the C-terminal tetrapeptide sequence (L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine) of the gastrins have been deduced. By pairing of the nucleotide bases in the conventional ‘Watson–Crick’ manner in both the antiparallel and the parallel direction of reading, complementary nucleotide sequences have been obtained. The syntheses are described of derivatives of the five tetrapeptides, L-glutamyl-L-isoleucyl-L-histidyl-L-proline, L-lysyl-L-isoleucyl-L-histidyl-L-proline, L-glutamyl-L-valyl-L-histidyl-L-proline, L-lysyl-L-valyl-L-histidyl-L-proline, and L-threonyl-L-tyrosyl-L-leucyl-L-lysine, whose sequences are coded by the complementary messenger nucleotide sequences.