Isothiazoles. Part XV. 5-Nitroisothiazoles
Abstract
3-Methyl-5-nitroisothiazole has been prepared from diazotised 5-amino-3-methylisothiazole and sodium nitrite. Oxidation gave the 3-carboxylic acid, which was converted into the amide, nitrile, aldehyde, and derivatives. Treatment of 3,5-dichloroisothiazole-4-carbonitrile with sodium nitrite gave 3-chloro-5-hydroxyisothiazole-4-carbonitrile.