Isothiazoles substituted in the 5-position by hydroxy-, alkoxy-, or amino-groups may be obtained by treatment of the corresponding methylsulphonyl compounds with the appropriate base. In some cases 3,5-disubstituted compounds may be prepared similarly.
M. Davis and J. A. Gordon, J. Chem. Soc., Perkin Trans. 1, 1972, 638 DOI: 10.1039/P19720000638
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