Issue 0, 1972

The structure of an amino-sugar from the antibiotic vancomycin

Abstract

Mild acid hydrolysis of the antibiotic vancomycin, previously known to liberate glucose, has been shown to liberate a second sugar formulated as 3-amino-2,3,6-trideoxy-3-C-methyl-lyxo-hexopyranose. On vigorous treatment with acid, under conditions previously shown to give vancomycin acid (3-methyl-4-oxohexanoic acid) from vancomycin. The novel amino-sugar affords vancomycin acid, thus establishing the origin of this acidic degradation product.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1972, 443-446

The structure of an amino-sugar from the antibiotic vancomycin

W. D. Weringa, D. H. Williams, J. Feeney, J. P. Brown and R. W. King, J. Chem. Soc., Perkin Trans. 1, 1972, 443 DOI: 10.1039/P19720000443

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