Heterocyclic studies. Part XXVI. Cleavage of pyrimido [5,4-e]-as-triazin-5(6H)-one by nucleophiles

Abstract

Pyrimido [5,4-e-]-as-triazin-5(6H)-one was readily cleaved by morpholine or 1,1-dimethylhydrazine to yield 6-amino-5-morpholinocarbonyl-as-triazine or the corresponding 5-NN-dimethylcarbohydrazide. The pyrimidotriazinone and hydroxylamine gave 6-hydroxypyrimide [5,4-e]-as-triazin-5(6H)-one, whereas the pyrimidotriazinone and methoxyamine gave methyl 6-(methoxyaminomethyleneamino)-as-triazine-5-carbohydroxamate.