A general method for the synthesis of β-lactam antibiotics substituted α to the β-lactum carbonyl is demonstrated by the reaction of the appropriate Schiff base-stabilized anion with a variety of reactive halide reagents.
W. A. Spitzer, T. Goodson, R. J. Smithey and I. G. Wright, J. Chem. Soc., Chem. Commun., 1972, 1138 DOI: 10.1039/C39720001138
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