Issue 18, 1972

An easy access to 5-mercaptopyrimidine nucleosides through one-step synthesis of 5-thiocyanato-uridine and -2′-deoxyuridine

Abstract

Reaction of uridine or 2′-deoxyuridine with thiocyanogen chloride gives the 5-thiocyanato-derivatives in good yield; this novel electrophilic substitution reaction of pyrimidine nucleosides opens a direct approach to the biologically active 5-mercaptopyrimidine nucleosides.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1972, 1025-1026

An easy access to 5-mercaptopyrimidine nucleosides through one-step synthesis of 5-thiocyanato-uridine and -2′-deoxyuridine

T. Nagamachi, P. F. Torrence, J. A. Waters and B. Witkop, J. Chem. Soc., Chem. Commun., 1972, 1025 DOI: 10.1039/C39720001025

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