An easy access to 5-mercaptopyrimidine nucleosides through one-step synthesis of 5-thiocyanato-uridine and -2′-deoxyuridine
Abstract
Reaction of uridine or 2′-deoxyuridine with thiocyanogen chloride gives the 5-thiocyanato-derivatives in good yield; this novel electrophilic substitution reaction of pyrimidine nucleosides opens a direct approach to the biologically active 5-mercaptopyrimidine nucleosides.