Lead tetra-acetate oxidation of NN-dimethylglycine and its relevance to the biosynthesis of the pyrrolidine ring of nicotine
Abstract
Validity of the degradation of the pyrrolidine ring of nicotine via NN-dimethylglycine hydrochloride has been confirmed since oxidation of the latter by lead tetra-acetate yields formaldehyde derived 98·7 ± 1·1% from the methylene group.