Validity of the degradation of the pyrrolidine ring of nicotine via NN-dimethylglycine hydrochloride has been confirmed since oxidation of the latter by lead tetra-acetate yields formaldehyde derived 98·7 ± 1·1% from the methylene group.
A. A. Liebman, B. P. Mundy, M. L. Rueppel and H. Rapoport, J. Chem. Soc., Chem. Commun., 1972, 1022 DOI: 10.1039/C39720001022
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