Issue 15, 1972

A useful method for α-methylation of γ-butyrolactones

Abstract

γ-Butyrolactone in tetrahydrofuran at –78° reacts with lithium di-isopropylamide or lithium iso-propylcyclohexylamide and then with an excess of deuterium oxide, methyl iodide, or allyl bromide to form α-deuterio-, α-methyl-, or α-allyl-γ-butyrolactone in good yield.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1972, 892-893

A useful method for α-methylation of γ-butyrolactones

G. H. Posner and G. L. Loomis, J. Chem. Soc., Chem. Commun., 1972, 892 DOI: 10.1039/C39720000892

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