Reductive cyclization of disubstituted pyridines and intramolecular aldolization of unsymmetrical diketones
Abstract
The relative proportions of alternative cyclohexenones formed on the one hand from systems of the type 2-CH2R,6-methylpyridine by reductive cleavage, and on the other hand from systems of the type Ac[CH2]3CO·CH2R by alkaline cyclization may be different and may depend on the steric requirements of R.