Reductive acylation of 5-nitropyridines with anhydrides of acetic, phthalic, and succinic acids

Abstract

A number of 2-substituted 5-nitropyridines have been submitted to reductive acylation with acid anhydrides. The yields of the acetamides, phthalamic, and succinamic acids produced do not appear to correlate with the electronic nature of the 2-substituent. A procedure for the formation of imides by cyclisation with dicyclohexylcarbodi-imide is presented. The hydrolysis products of some of the pyridyl amides and imides are discussed. N.m.r. data for some 2,5-disubstituted pyridines are presented.