Total synthesis of polymethoxyoestrane compounds. Part II. Synthesis of (±)-2,4-dimethoxyoestra-1,3,5(10)-trien-17β-ol
Abstract
(±)-2,4-Dimethoxyoestra-1,3,5(10)-trien-17β-ol (7; R1= R3= OMe, R2= H), synthesized from 5,7-dimethoxy-1-tetralone (1), was found to be identical with the demethoxylated product obtained by metal–ammonia reduction of 2,3,4-trimethoxyoestra-1,3,5(10),8-tetraen-17β-ol (6; R1= R2= R3= Me).