Issue 0, 1971

Studies on the syntheses of heterocyclic compounds. Part CCCLXXXIX. An alternative synthesis of de-ethyldasycarpidone

Abstract

The synthesis of (±)-de-ethyldasycarpidone (V) is described. The key step involves condensation of indolylmagnesium bromide with methyl isonicotinate 1-oxide to afford the pyridylindole (VI). Hydrogenation of the methiodide of the latter over platinum yielded a mixture of stereoisomers of the amino-esters (X). Normal saponification of the compound (Xa) afforded the amino-acid (XI) which was heated with polyphosphoric acid to give de-ethyldasycarpidone (V).

Article information

Article type
Paper

J. Chem. Soc. C, 1971, 1053-1054

Studies on the syntheses of heterocyclic compounds. Part CCCLXXXIX. An alternative synthesis of de-ethyldasycarpidone

T. Kametani and T. Suzuki, J. Chem. Soc. C, 1971, 1053 DOI: 10.1039/J39710001053

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