The mechanism described by Brenner for the aminoacyl insertion reaction as applied to the synthesis of peptides is considered; spectroscopic and kinetic evidence is presented for an alternative mechanism involving diacylamine intermediates. The relevance of these results to Woodward's use of the N-ethylbenzisoxazolium cation in the synthesis of peptides is also discussed.
P. L. Russell, R. M. Topping and D. E. Tutt, J. Chem. Soc. B, 1971, 657 DOI: 10.1039/J29710000657
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