Reaction of Me2CuLi with the diethyl acetal of ethyl 2-oxobutyrate gives the synthetically useful methyl ketone(I) in nearly quantitative yield; similarly, acetophenone is formed in good yield from the reaction of ethyl benzoate and Me2CuLi.
S. A. Humphrey, J. L. Herrmann and R. H. Schlessinger, J. Chem. Soc. D, 1971, 1244 DOI: 10.1039/C29710001244
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