An efficient conversion of diosgenin into 22-oxocholesterol
Abstract
Diosgenin has been converted in 50% overall yield into a 1 : 1 mixture of 20S- and 20R-22-oxocholesterols, from which the 20S-22-ketone (containing the natural stereochemistry at C-20) can be isolated in good yield via a repreated equilibration procedure.