(±)-Cularine (I) has been synthesised via oxidative coupling of the diphenolic benzylisoquinoline (III); preparation of the latter involved a new and mild variant of the Pomerantz-Fritsch isoquinoline synthesis followed by application of the Reissert procedure.
A. H. Jackson and G. W. Stewart, J. Chem. Soc. D, 1971, 149 DOI: 10.1039/C29710000149
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