A method for the determination of disodium cromoglycate and other chromones

Abstract

The hydrolysis of disodium cromoglycate in alkaline solution has been studied and a method for its determination is presented. The method is based on spectrophotometric measurement of the change in absorption at 310 nm, which takes place on opening the γ-pyrone ring of the chromone nucleus. The technique is applicable, with suitable minor modifications, to the determination of other compounds containing the chromone nucleus, such as flavones.