Synthesis of derivatives of thiazolo[4,5-d]pyrimidine. Part II

Abstract

An attempt to prepare thiazolo[4,5-d]pyrimidine-5,7-diol by the action of potassium hypobromite on thiazole-4,5-dicarboxamide revealed the instability of the thiazole portion of this condensed ring system when 2-substituents are lacking. The product obtained was bis-(4-amino-2,6-dihydroxpyrimidin-5-yl) disulphide, contrary to an earlier report. A number of thiazolo [4,5-d]pyrimidines have been prepared by cyclisation of the corresponding 4-aminopyrimidin-5-yl thiocyanates. Deamination of aminothiazolo[4,5-d]pyrimidines, with nitrous acid, has given a number of derivatives among which is the analogue of uric acid.