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Issue 16, 1970
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Benzopyrones. Part I. 6-Amino- and 6-hydroxy-2-substituted chromones

Abstract

Contrary to a report in the literature, mono- and di-nitration of 6-hydroxy-2-methylchromone (I) gives the 5-nitro- and the 5,7-dinitro-derivative according to the conditions. 2,5-Dihydroxy-3-nitroacetophenone, whose m.p. is given erroneously in the literature, has been synthesized. The earlier literature on mono- and di-bromination of (I) is corrected and the structure of each product is elucidated.

4-Oxochromen-2-carboxylic acid and its ethyl ester have been nitrated; the catalytic hydrogenation of the resulting 6-nitro-compound has been studied; according to the conditions, the products are the 6-hydroxyamino-and the 6-amino-chromone (VIII), and the 6-aminochromanone. Diazotization of (VIII) followed by hydrolysis gave 6-hydroxy-4-oxochromen-2-carboxylic acid.

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Article information


J. Chem. Soc. C, 1970, 2230-2233
Article type
Paper

Benzopyrones. Part I. 6-Amino- and 6-hydroxy-2-substituted chromones

G. Barker and G. P. Ellis, J. Chem. Soc. C, 1970, 2230
DOI: 10.1039/J39700002230

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