Issue 15, 1970

Purines, pyrimidines, and imidazoles. Part XXXIII. Synthesis of 5-methylsulphonyluridine and its 5′-mono- and pyro-phosphates

Abstract

5-Methylthiouridine tri-O-benzoate and 5-methylsulphonyluridine have been prepared. The latter gave a crystalline triacetate and an isopropylidene derivative, which when phosphorylated by different methods gave via the intermediate 2′,3′-isopropylidene-5-methylsulphonyluridine 5′-phosphate, 5-methylsulphonyluridine 5′-phosphate. The monophosphate was converted into the corresponding pyrophosphate in various ways. The reactions and preparations of some of the intermediates are discussed.

Article information

Article type
Paper

J. Chem. Soc. C, 1970, 2016-2022

Purines, pyrimidines, and imidazoles. Part XXXIII. Synthesis of 5-methylsulphonyluridine and its 5′-mono- and pyro-phosphates

J. M. Carpenter and G. Shaw, J. Chem. Soc. C, 1970, 2016 DOI: 10.1039/J39700002016

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