An efficient method for the side-chain cleavage of acetylated cucurbitacins with lead tetra-acetate is described. This reaction afforded 4,4,14α-trimethyl-19(10 → 9β)abeo-10α-pregn-5-ene derivatives of cucurbitacins A, B, C, and E, and further degradation of the cleavage products of cucurbitacins A and B led to A-ring ketones.
J. R. Bull and K. B. Norton, J. Chem. Soc. C, 1970, 1592 DOI: 10.1039/J39700001592
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