Synthesis of benzophenones: anomalous Friedel–Crafts reactions
Abstract
A Friedel–Crafts reaction between 2,6-dimethoxybenzoyl chloride and benzene yields 2,6-dimethoxybenzophenone and 3-benzoyl-2,2′,4,6′-tetramethoxybenzophenone, and under milder conditions, 3-carboxy-2,2′,4,6′-tetramethoxybenzophenone. A synthesis and the degradation under acid conditions of 3-benzoyl-2,2′,4,6′-tetramethoxybenzophenone are described.