SCHEDULED MAINTENANCE:
Tetracyclines, and ring A models, are converted by trimethylchlorosilane and hexamethyldisilazane in pyridine into trimethylsilyl derivatives which dissolve readily in common solvents. This has facilitated the use of n.m.r. and i.r. spectra in elucidating the molecular structures of tetracyclines.
C. H. Hassall and G. J. Thomas, J. Chem. Soc. C, 1970, 636 DOI: 10.1039/J39700000636
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