Cytotoxic compounds. Part X. Carbamates derived from NN-bis-(2-chloroethyl)-m- and NN-bis-(2-chloroethyl)-p-phenylenediamine
Abstract
Urethanes have been prepared by reaction of the amines m-RNH2 or p-RNH2[R = C6H4·N(CH2·CH2Cl)2] with chloroformates. The products, after removal of protecting groups, include p-RNH·CO·O·C6H4·CO2H (o-, m-, and p-), m-RNH·CO·O·C6H4·CO2H(m-), O-(p-RNH·CO)-serine, and O-(p-RNH·CO)-threonine. Terephthalic amides, (p-RNH·CO)2C6H4 and (p-RNH·CO)C6H4·CO2Me, and phthalimides, C6H4(CO)2NR (m- and p-), are also described.