Incorporation experiments with [7-14C]-5,7-dihydroxyphthalide (II), [7-14C]-6-gerany-5,7-dihydroxyphthalide (IV), [7-14C]-5,7-dihydroxy-4-methylphthalide (V), and [7-14C]-7-hydroxy-5-methoxy-4-methylphthalide (VI) suggest that only [7-14C]-5,7-dihydroxy-4-methylphthalide (V) acts as the principal precursor of mycophenolic acid.
L. Canonica, W. Kroszczynski, B. M. Ranzi, B. Rindone and C. Scolastico, J. Chem. Soc. D, 1970, 1357 DOI: 10.1039/C29700001357
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