Preferential cleavage of trimethoxy-substituted 1,2,3,4-tetrahydroisoquinoline alkaloids
Abstract
Controlled O-demethylation of vicinal trimethyoxy-substituted 1,2,3,4-tetrahydroisoquinolies with 20% hydrochloric acid cleaves certain substrates to afford a diphenol, together with the expected monophenol.