The effects of temperature, the substitution pattern at C-5 and C-6, and the base are employed to delineate the conditions for proton abstraction from C-6 of the penicillin nucleus by carbanion or β-elimination pathways.
S. Wolfe, W. S. Lee and R. Misra, J. Chem. Soc. D, 1970, 1067 DOI: 10.1039/C29700001067
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