A new approach to the introduction of corticoid-like C-17 functions via 2-lithio-1,3-dithian–epoxide reactions
Abstract
The reactions of the 2-methyl-1,3-dithian anion with the 17α- and 17β-epimers of 3,3′-ethylenedioxy-17-oxiranylandrost-5-ene have been used to illustrate the potential of dithian–epoxide reactions for the introduction of homocorticoid and homoprogestogen types of functions at C-17 of the steroid skeleton.