Cyclization of one of two bisamides (V) and VI), followed by reduction and methylation, gave the expected biscoclaurine derivatives (one of which was identical with O-methyloxyacanthine) thus completing the total synthesis of obaberine (I).
T. Kametani, K. Wakisaka and K. Kigasawa, J. Chem. Soc. D, 1970, 277 DOI: 10.1039/C29700000277
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