A new and efficient approach, which involves the applications of substituted phenols, (i) as 5′-phosphate protecting group and (ii) to increase the binding property of the nucleotidic fragment to benzoylated DEAE-cellulose, has been developed successfully for the synthesis of deoxyribo-oligonucleotides.
S. A. Narang, O. S. Bhanot, J. Goodchild and R. Wightman, J. Chem. Soc. D, 1970, 91 DOI: 10.1039/C29700000091
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