Novel analgesics and molecular rearrangements in the morphine–thebaine group. Part XV. Ozonolysis of derivatives of 6,14-endo-ethenotetrahydrothebaine

Abstract

Fission of the aromatic nucleus in bases of the 6,14-endo-Ethenotetrahydrothebaine series by ozonolysis affords lactonic esters still exhibiting marked analgesic properties, contrary to what would be expected on the basis of previously accepted theories of the nature of the ‘analgesic receptor.’ Simpler synthetic analogues of these ozonolysis products show no such activity.