Derivatives of 2,3,4,5,6-penta-O-benzyl-myo-inositol

Abstract

A convenient synthesis of racemic 1,2-O-isopropylidene-myo-inositol is described. This compound was converted into racemic 2,3,4,5,6-penta-O-benzyl-myo-inositol by making use of the allyl ether group for protection. An optically active 2,3,4,5,6-penta-O-benzyl-myo-inositol was also obtained from galactinol. Racemic 2,3,4,5,6-penta-O-benzyl-myo-inositol monoesters of phthalic, succinic, phosphoric, phenylphosphoric, and benzyl-phosphoric acids were prepared for the purpose of resolution and as intermediates for a proposed synthesis of phosphatidylinositol.