Orientation effects in the nitration of some 6- and 7-monosubstituted and 6,7-disubstituted quinolines
Abstract
The directive effects in the nitration under standard conditions of a series of substituted 4-chloroquinolines and 4-quinolones are discussed. 6-Methyl and 6-methoxy-substituents direct the nitronium ion into the 5-position whereas a 7-chloro-substituent directs this ion into the 8-position.