An improved procedure for the preparation of 1-benzylisoquinolines in high overall yields via Reissert compound intermediates has been developed. It involves generation of the C-1 carbanion of the Reissert compound with sodium hydride in dimethylformamide.
B. C. Uff and J. R. Kershaw, J. Chem. Soc. C, 1969, 666 DOI: 10.1039/J39690000666
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