Potential coenzyme inhibitors. Part II. Reduction of 4-methylnicotinamide derivatives by sodium dithionite and sodium borohydride

Abstract

The preparation of some 4-methylnicotinamide derivatives is described, and the dithionite and borohydride reduction products are compared with those from the corresponding nicotinamide derivatives. The u.v. absorption and ¹H n.m.r. spectra show that in each case 1,4-dihydronicotinamides are formed from the dithionite reactions, whilst borohydride reductions yield 1,6-dihydro-derivatives.