Cyanochlorination and cyanogenation of isoquinoline
Abstract
Isoquinoline reacts with potassium cyanide and sulphuryl chloride to give, depending upon the reaction conditions, 4-chloro-1-cyano-, 1,3-dicyano-, 1-aminocarbonyl-3-cyano-, 3-cyano-, and 1-cyano-isoquinoline, thus illustrating a simple method for the direct introduction of chloro- and cyano-substituents into nitrogen heterocycles.