Enzymic formation of a tricyclic sesterterpene alcohol from mevalonic acid and all-trans-geranylfarnesyl pyrophosphate
Abstract
Mevalonic acid lactone and the chemically synthesized all-trans-geranylfarnesyl pyrophosphate are converted into a tricyclic sesterterpene alcohol, ophiobolin F, by incubation with 100,000 ×g supernatant fraction from cell-free system of Chochlibolus heterostrophus.