The stereochemical origin of the C-22 hydrogen atoms of cholesterol
Abstract
The 22-pro-R and 22-pro-S protons of cholesterol are derived from the 2-pro-R and 2-pro-S protons of mevalonic acid, respectively, and the protozoan T. pyriformis is shown to eliminate the 7β- and 22-pro-R hydrogens of cholesterol in the conversion into cholesta-5,7,22-trien-3β-ol.