The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Stereochemistry of homosterol formation from 1-methylsqualene 2,3-oxide
Abstract
Squalene 2,3-oxide lanosterol cyclase selectively converts the 1′-cis-methyl isomer as a component in a mixture of cis- and trans-1-methylsqualene 2,3-oxides into 4α-ethyl-4β,14α-dimethylcholesta-8,24-dien-3β-ol.