Gas-chromatographic determination of acetyl and trimethylsilyl derivatives of alkyl carbamates and their N-hydroxy derivatives

Abstract

Microgram amounts of mixtures of alkyl carbamates, and of urethane and N-hydroxyurethane, as their trimethylsilyl derivatives, and similar mixtures of alkyl N-hydroxycarbamates, as their trimethylsilyl and acetyl derivatives, have been analysed by gas chromatography on SE30 columns. With a programmed temperature rise, the elution temperatures varied linearly with the number of carbon atoms in the alkyl side-chain of a homologous series; the isobutyl analogues were eluted at lower temperatures than the corresponding butyl analogues. When the corresponding isobutyl derivatives were used as internal standards, the ratios of peak heights (test to standard) varied linearly with the concentration of urethane and N-hydroxyurethane.