Pyrano[4,3-d]pyrimidin-5-ones, formed by the action of bromine in acetic acid on 4-styrylpyrimidine-5-carboxylic acids, yield pyrido[4,3-d]pyrimidin-5(6H)-ones on treatment with amines. Nucleophilic replacement reactions of some 5-substituted pyrido[4,3-d]pyrimidines are reported.
A. G. Ismail and D. G. Wibberley, J. Chem. Soc. C, 1968, 2706 DOI: 10.1039/J39680002706
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