The configurations of the 1,3,4,7-tetramethylisoindolines have been assigned on the basis of the equivalence or otherwise of the methylene protons in the N-benzyl and N-neopentyl derivatives. The isomer of lower m.p. has the cis-configuration. The acid-catalysed thermal equilibration of the isomers has been demonstrated.
C. O. Bender and R. Bonnett, J. Chem. Soc. C, 1968, 2186 DOI: 10.1039/J39680002186
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