Nucleosides. Part VI. The formation of anomeric nucleosides from the silver salt of hypoxanthine

Abstract

The silver salt of hypoxanthine condenses with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in xylene to give a mixture of products which after deacetylation and separation yielded both α- and β-anomers of 7- and 9-D-glucopyranosylhypoxanthine. In addition several substituted imidazoles are produced which are formed from various N¹-substituted hypoxanthines under the alkaline conditions used in the separation.