The resolution of 2-(α-hydroxybenzyl)-1,4,5,6-tetrahydropyrimidines and a comparison of their optical rotary dispersion curves with those of related mandelic acid derivatives

Abstract

Six 2-(α-hydroxybenzyl)-1,4,5,6-tetrahydropyrimidines (IIa–f) have been prepared and four of them (IIa, b, d, and f) have been resolved by means of the mandelic acids. O.r.d. has been applied to the determination of the configuration of these compounds, and some general comments are made on the behaviour of the phenyl chromophore as found in substituted mandelic acid systems.