Racemisation. Part II. Racemisation of 1-benzyltetrahydroisoquinolines under the conditions of catalytic hydrogenation
Abstract
Treatment of optically active 1-benzyltetrahydroisoquinolines, namely L-(+)-laudanosine, L-(–)-norlaudanosine, L-(+)-7-benzyloxy-1,2,3,4-tetrahydro-1-(4-hydroxybenzyl)-6-methoxy-2-methylisoquinoline, and D-(–)-N-methylcoclaurine with hydrogen in the presence of Adams catalyst under the conditions of catalytic hydrogenation afforded the corresponding racemates.