Synthesis of δ-aminolaevulinic acid analogues as potential antimalarial agents

Abstract

As part of a study of the synthesis of potential antimalarial agents, a number of analogues of δ-aminolaevulinic (5-amino-4-oxopentanoic) acid were prepared: (1) methyl 5-(morpholino-, piperidino-, or N-methylbenzyl-amino-)4-oxopentanoate, (2) 1-amino-4-(phenyl- or p-chlorophenyl)sulphonylbutan-2-one hydrochloride, (3) 1-(benzoyl- or nicotinoyl-)2-glycylhydrazine hydrobromide, (4) 1-glycyl-2-(p-tolyl- or p-chlorophenyl-)-sulphonylhydrazine hydrobromide, (5) glycine phenacyl- or p-bromophenacyl-amide hydrobromide, (6) glycine 2-(phenyl- or p-tolyl-)sulphonylethylamide hydrobromide, and (7) 1-ethoxycarbonyl-2-glycylhydrazine hydrochloride.