A kinetic study of the displacement of fluorine and chlorine from the benzo-ring of quinazoline by methoxide ions in methanol showed the order of reactivity at the different positions to be 7- > 5- > 6- and 8-, and the fluorosubstituent was displaced more readily than the chloro-substituent. The Arrhenius parameters for these reactions are given.
W. L. F. Armarego and J. I. C. Smith, J. Chem. Soc. B, 1968, 407 DOI: 10.1039/J29680000407
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